What to Expect from Grey’s Anatomy Season 22 Episode 5: Sometimes I Feel Like a Motherless Child
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Simone treats a patient with a connection to her mother on Grey’s Anatomy Season 22 Episode 5, “Sometimes I Feel Like a Motherless Child.”
In the promo video for the episode (watch it below), Simone greets the patient, then sees that the patient has a photo of her mother. Meanwhile, Jo has a difficult case with a pregnant mother, and Blue and Jules go above and beyond for a patient — possibly more than they should.
Link also seems to be in good spirits, now back to work after recovering from his injuries, and Jo is getting closer to her due date.
Here’s everything you need to know about this episode, including the air date, cast, promo, and how to watch.
- Title: “Sometimes I Feel Like a Motherless Child”
- Air Date: Thursday, November 6th, 2025
- Time: 10/9c
- Network: ABC
- Main cast: Chandra Wilson, Kevin McKidd, Kim Raver, James Pickens Jr., Chris Carmack, Camilla Luddington, Anthony Hill, Jason George, Alexis Floyd, Adelaide Kaine, Harry Shum Jr., Nico Terho, Trevor Jackson, Ellen Pompeo
- Live: ABC at 10/9c
- Streaming: Available next day on Hulu
Grey’s Anatomy Season 22 Episode 5 Description
Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.
Promo Video:
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Grey’s Anatomy airs Thursdays at 10/9c on ABC.