Grey’s Anatomy season 22 episode 5 release date and time: Jo takes centre stage in upcoming emotional chapter – preview inside
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Grey’s Anatomy season 22 episode 5, “Sometimes I Feel Like a Motherless Child,” airs on November 6, 2025. The episode focuses on Jo Wilson’s emotional medical case, Blue and Jules’ teamwork, and Simone’s big discovery. Find out the release time and streaming details for the hit ABC drama.
Grey’s Anatomy fans are in for another emotional ride as the doctors of Grey Sloan Memorial return with more intense medical cases and personal challenges. Season 22 has already delivered heartwarming and heartbreaking moments, and the upcoming episode promises to continue that streak. Episode 5 is set to focus on Jo Wilson’s toughest day yet as both a doctor and an expectant mother, bringing a mix of drama, emotion, and life lessons that the show is loved for.
Grey’s Anatomy season 22 episode 5 preview
Episode 5 of Grey’s Anatomy season 22 will put Jo Wilson in the spotlight as she faces one of the most difficult cases of her career while being heavily pregnant herself. Treating an expectant mother with severe complications, Jo finds her personal and professional worlds colliding in an emotional way.
( Image credit : ABC | Grey’s Anatomy season 22, episode 5 will release on Nov 6. )
Meanwhile, doctors Blue and Jules deal with a diabetic patient whose condition suddenly worsens, testing their teamwork and quick decision-making under pressure. Adding to the drama, Simone makes a surprising discovery about her patient, leading to an emotional reveal that ties into the episode’s larger theme of strength, healing, and self-discovery.
When and where to watch Grey’s Anatomy season 22 episode 5
The fifth episode, titled “Sometimes I Feel Like a Motherless Child,” will air on Thursday, November 6, 2025, at 10 PM ET / 9 PM CT on ABC. For viewers who prefer streaming, the episode will be available on Hulu the following day. Hulu offers flexible subscription plans, including the Disney+ and Hulu bundle for $12.99 per month with ads or $19.99 per month for the ad-free experience.
( Image credit : ABC | Grey’s Anatomy season 22 fifth episode is titled “Sometimes I Feel Like a Motherless Child.” )
( Image credit : ABC | Grey’s Anatomy continues to tug at heartstrings. )
Grey’s Anatomy season 22 episode schedule
Season 22 premiered on October 9, 2025, and new episodes have been released weekly every Thursday. Here’s a quick look at the schedule so far:
Oct 9—Episode 1: “Only the Strong Survive”
Oct 16—Episode 2: “We Built This City”
Oct 23—Episode 3: “Between 2 Lungs”
Oct 30—Episode 4: “Goodbye Horses”
Nov 6—Episode 5: “Sometimes I Feel Like a Motherless Child”
Nov 13—Episode 6: Fall Finale (Title TBA)
After the fall finale, the series will take a short break.
When will Grey’s Anatomy return after the break?
Usually, ‘Grey’s Anatomy’ goes on a long winter break, but this time, fans won’t have to wait as long. The show is set to return much earlier than expected, on Thursday, January 8, 2026. With its emotional storytelling, evolving characters, and powerful performances, the upcoming episodes promise to keep viewers glued to their screens.